>98%
Purity HPLC
COA
Every batch
EU
Fulfilment
Discreet
Shipping
TB-500 corresponds to the active region of Thymosin Beta-4 (AcSDKPDMAEIEKFDKSKLKKTETQ), the fragment responsible for the majority of its biological activity. It plays a central role in actin regulation, cell migration, and tissue repair, making it one of the most studied peptides in regenerative research.
Research has focused on its ability to promote angiogenesis, accelerate wound healing, reduce inflammation, and support recovery from both acute and chronic tissue injury. TB-500 has demonstrated systemic effects following administration, meaning its regenerative activity is not limited to the site of application.
Unlike many repair-focused peptides, TB-500 also demonstrates meaningful effects on cardiac tissue and the central nervous system, with studies documenting neurogenesis and cardiac repair following injury.
Key research areas include:
– Muscle and soft tissue repair
– Tendon and ligament healing
– Angiogenesis and vascular repair
– Anti-inflammatory activity
– Cardiac tissue regeneration
– Neurogenesis following CNS injury
- Actin Regulation & Cell Migration
TB-500’s primary mechanism involves binding to G-actin, sequestering it and promoting cell migration — a critical step in tissue repair. This actin-regulatory activity underlies many of its downstream regenerative effects across tissue types. - Angiogenesis
Studies have demonstrated TB-500’s ability to promote formation of new blood vessels through upregulation of vascular endothelial growth factor (VEGF) receptors, improving blood supply to damaged tissue and accelerating the healing cascade. - Muscle & Soft Tissue Repair
Animal studies have documented accelerated recovery from muscle injury, reduced fibrosis, and improved functional outcomes following TB-500 administration. Its effects on satellite cell activation support muscle regeneration at the cellular level. - Anti-Inflammatory Activity
TB-500 consistently reduces inflammatory markers across tissue types, modulating the local inflammatory environment to support repair without suppressing the immune response entirely. - Cardiac Regeneration
Research has documented TB-500’s ability to stimulate cardiac stem cell migration and differentiation following myocardial infarction in animal models, representing a unique area of study among repair peptides.
Key References:
– Goldstein AL et al. Thymosin beta-4: a multi-functional regenerative peptide. Expert Opin Biol Ther. 2012.
– Smart N et al. Thymosin beta-4 induces adult epicardial progenitor mobilisation. Nature. 2007.
– Philp D et al. Thymosin beta-4 and the heart. Ann N Y Acad Sci. 2012.- Actin Regulation & Cell Migration
| Parameter | Detail |
| Peptide | TB-500 (Thymosin Beta-4 Fragment) |
| Sequence | Ac-SDKPDMAEIEKFDKSKLKKTETQ |
| Molecular Weight | 4963.44 g/mol |
| CAS Number | 77591-33-4 |
| Appearance | White lyophilised powder |
| Purity | >99% (HPLC) |
| Vial Size | 10mg |
| Storage | -20°C, protect from light and moisture |
| Reconstitution | Bacteriostatic water or sterile saline |
| Shelf Life | 24 months (lyophilised) / 30 days (reconstituted, refrigerated) |
| Format | Lyophilised powder, single-use research vial |
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