>98%
Purity HPLC
COA
Every batch
EU
Fulfilment
Discreet
Shipping
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences as a stabilised derivative of tuftsin. It demonstrates a strong anxiolytic profile without the sedative or dependencyforming effects associated with classical benzodiazepines.
Research has focused on its ability to modulate the GABAergic system, regulate expression of brain-derived neurotrophic factor (BDNF), and influence serotonin and dopamine metabolism. Its effects on anxiety and cognitive performance have been documented across numerous preclinical and early clinical studies.
Selank has received approval in Russia as an anxiolytic drug, and has been studied in clinical settings for generalised anxiety disorder and neurasthenia, providing a meaningful clinical reference point for researchers.
Key research areas include:
– Anxiolytic activity without sedation or dependency
– BDNF expression and synaptic plasticity
– Serotonin and dopamine metabolism modulation
– Memory consolidation and learning
– Immune system modulation via tuftsin activity
– Stress response regulation
- Anxiolytic Activity
Selank has demonstrated consistent anxiolytic effects across animal models of stress and anxiety, comparable in magnitude to diazepam in some studies, without associated sedation or withdrawal effects. Its mechanism is believed to involve GABAergic modulation and influence on enkephalin metabolism. - BDNF Upregulation
Studies have shown Selank increases BDNF expression in the hippocampus, supporting its observed effects on memory and learning. BDNF upregulation is associated with improved synaptic plasticity and long-term potentiation. - Serotonin & Dopamine Modulation
Research has documented Selank’s ability to regulate serotonin degradation rates and influence dopaminergic activity in the brain, providing a neurochemical basis for its mood-stabilising and cognitive-enhancing effects. - Immune Modulation
As a tuftsin analogue, Selank retains immunomodulatory activity. Studies have demonstrated effects on T-cell activity, cytokine expression, and overall immune function, suggesting potential utility in stress-induced immune suppression models. - Cognitive Enhancement
Animal studies have shown improvements in memory consolidation, attention, and learning under Selank administration, particularly under conditions of stress or cognitive load.
Key References:
– Semenova TP et al. Selank and anxiety: behavioural and neurochemical study. Bull Exp Biol Med. 2010.
– Zozulya AA et al. The anxiolytic and nootropic drug Selank. Drugs R D. 2001.
– Uchakina ON et al. Immunomodulatory effects of Selank in patients with anxiety disorders. Zh Nevrol Psikhiatr. 2008.- Anxiolytic Activity
| Parameter | Detail |
| Peptide | Selank (Tuftsin Analogue) |
| Sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro |
| Molecular Weight | 751.86 g/mol |
| CAS Number | 129954-34-3 |
| Appearance | White lyophilised powder |
| Purity | >>99% (HPLC) |
| Vial Size | 10mg |
| Storage | -20°C, protect from light and moisture |
| Reconstitution | Bacteriostatic water or sterile saline |
| Shelf Life | 24 months (lyophilised) / 30 days (reconstituted, refrigerated) |
| Format | Lyophilised powder, single-use research vial |
Reviews
There are no reviews yet.