>98%
Purity HPLC
COA
Every batch
EU
Fulfilment
Discreet
Shipping
GHK-Cu (Gly-His-Lys:Cu2+) was first isolated from human plasma in 1973 and has since become one of the most extensively characterised copper peptides in biomedical research. Its plasma concentration declines significantly with age, a finding that has driven substantial interest in its role in tissue maintenance and regeneration.
Research has demonstrated GHK-Cu’s ability to activate a broad range of repair and remodelling processes, including collagen and glycosaminoglycan synthesis, angiogenesis, anti-inflammatory signalling, and antioxidant gene expression. It has also been shown to modulate over 4,000 human genes in a direction associated with tissue health and repair.
GHK-Cu’s broad genomic activity — documented through gene array studies — distinguishes it from more targeted peptides and positions it as a systemic regulatory compound with wide-ranging research applications.
Key research areas include:
– Collagen and extracellular matrix synthesis
– Wound healing and skin repair
– Anti-inflammatory and antioxidant activity
– Angiogenesis
– Neuroprotection and nerve regeneration
– Gene expression modulation
- Collagen Synthesis & Skin Remodelling
GHK-Cu has been shown to stimulate synthesis of collagen, elastin, and glycosaminoglycans in fibroblasts, with studies documenting significant improvements in skin thickness, firmness, and wound closure rates across both in vitro and animal models. - Gene Expression Modulation
Gene array studies have demonstrated that GHK-Cu modulates expression of over 4,000 human genes, predominantly in a direction associated with tissue repair, reduced inflammation, and metabolic health. This broad genomic activity is unique among short peptides. - Anti-Inflammatory & Antioxidant Activity
GHK-Cu consistently reduces expression of pro-inflammatory cytokines and upregulates antioxidant defence genes including superoxide dismutase and catalase, providing protection against oxidative damage in tissue repair models. - Angiogenesis
Studies have documented GHK-Cu’s ability to promote new blood vessel formation, improving vascular supply to damaged or ageing tissue — a key factor in sustained regenerative activity. - Neuroprotection
Research has explored GHK-Cu’s neuroprotective potential, with studies demonstrating reduction in markers of neurodegeneration and support for nerve growth factor expression in relevant models.
Key References:
– Pickart L et al. GHK-Cu and tissue repair. Organogenesis. 2008.
– Pickart L & Margolina A. Regenerative and protective actions of GHK-Cu peptide. Biomolecules. 2018.
– Pollard JD et al. Copper tripeptide complex as a modulator of gene expression. J Investig Dermatol. 2005.- Collagen Synthesis & Skin Remodelling
| Parameter | Detail |
| Peptide | GHK-Cu (Copper Peptide Complex) |
| Sequence | Gly-His-Lys : Cu2+ |
| Molecular Weight | 403.91 g/mol |
| CAS Number | 49557-75-7 |
| Appearance | Blue lyophilised powder |
| Purity | >99% (HPLC) |
| Vial Size | 50mg |
| Storage | -20°C, protect from light and moisture |
| Reconstitution | Bacteriostatic water or sterile saline |
| Shelf Life | 24 months (lyophilised) / 30 days (reconstituted, refrigerated) |
| Format | Lyophilised powder, single-use research vial |
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